From Microfluidics to 3D Bioprinting for Human/Organs-on-Chips Development
The development of a new drug spends 15 years and 2.6$ millions, and 95% drugs fail in clinical trial. While the preclinical cell culture and animal model fail to predict drug testing in human, the reconstruction of human physiology-on-Chips from human cells will accelerate drug discovery by reducing the time and the cost of drug. Microfluidic technology has been showed the crucial tool to reconstruction mimetic human/organs by controlling microstructures and fluids in microscale with the same scale of cells. Here, the novel microfluidic construction precisely defined, minimalistic brain models ‘’Brain-on-Chip’’ will be discussed.
Recently, 3D bioprinting demonstrates the powerful tool for the reconstruction tissue/organ by the bottom up assembling cells into tissue/organ. The resolution is one the most important challenge to solve due to the complexity of tissue organs structure. Light is appropriate method to accurately control individual objects and could help to reconstruct precise tissue organ structure. A pioneering new technique near infrared light (NIR) laser for printing and assembling building blocks will be presented.
Ph.D at National University of Singapore
Ngoc Duy is a Ph.D candidate at Department of Biomedical Engineering (BME), National University of Singapore (NUS). He will finish his study in December, 2018. Before, NUS, he was the scientist in Miniaturisation for Life Sciences Group, Institute of Analytical Science, Dortmund, Germany, focusing on Brain-on-Chip project collaboration with Dr. Jean-Michel. Peyrin (neurobiologist, Institute of Biology Paris-Seine, France) who founded the MicroBrain Biotech company and Neurotoxicology and Chemosensation Group, Leibniz Insititute, Germany. The works were published on Lab Chip, JoVE, Springer Book. The team sent out the chips for first ordering to Prof Tsuneya Ikezu, MD, PhD, Department of Pharmacology & Experimental Therapeutics and Neurology, Alzheimer’s Disease Center, Boston University School of Medicine.
In NUS, he develops a novel NIR laser 3D bioprinting for constructing tissues or organs. The work was published on Small, Wiley. It was selected cover feature and highlighted in AdvancedScienceNews (Wiley) and several 3D Bioprinting media from industry. Our NIR laser 3D Bioprinting technology has been attracted by several 3D Bioprinting start-up companies. We are negotiating with Fluxbio, a 3D Bioprinting start-up company based on Electrospray technology for commercial.
Duy has authored and co-authored prestigious scientific publications on Nature Communications, Advanced Functional Materials, Small, Lab-on-a-Chip, 1 book chapter, and 1 patent. He got the award from The Chemical and Biological Microsystems Society (CBMS) and sort list (4/130) the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) innovation award.