Nanoscale aspects of a human multi-organ-chip platform for safety and efficacy testing
Microphysiological systems have proven to be a powerful tool for recreating human tissue- and organ-like functions at research level. Thirteen different single organ equivalents have been established on TissUse´s Multi-Organ-Chip (MOC) platform and twelve organ combinations have been tested for stable long-term crosstalk yet. Examples of industrial transfer of single-organ chip and two-organ chip solutions, hosting a human 3D bone marrow model and a liver pancreatic islet co-culture respectively, are highlighted. Challenges to translate a MOC-based combination of four human organ equivalents into a commercially useful tool for ADME profiling and toxicity testing of drug candidates are illustrated. Nanoscale aspects are discussed along with the introduction of the Multi-Organ-Chip platform.
CEO and founder of TissUse GmbH
Since 2010 Uwe Marx is the CEO and founder of TissUse GmbH, a spin-out Company of the Technische Universität Berlin, Germany. The company is developing and commercializing a Multi-Organ-Chip platform. Between March 2010 and September 2015 Dr. Marx was the leader of a multi-organ-chip program at the Technische Universität Berlin. Prior to that Uwe Marx joined ProBioGen – a biotech Company he founded in 1994 – as the Chief Scientific Officer. He is a physician by training and received his doctorate degree in immunology from the Humboldt University in Berlin. He has published more than 60 peer-viewed papers and is inventor in more than 25 patent families. In addition to his current company, TissUse, he is the founder of the two successful German biotechs – Vita 34 and ProBioGen.